Harvard/Medical Systems Neuro Phore BH-2 System

In the past few decades, the application of drugs and other dissolved agents from multibarrel electrodes/pipettes has evolved into a practical method of testing their effects on cells or cellular systems. The versatile Neuro Phore BH-2 System is designed to facilitate controlled ejection of fluids from multibarrel micropipettes. Extracellular ejections of minute volumes can be delivered using up to five

pumps in serial or parallel. The ejection schedule for each pump can be independently programmed for sequential or simultaneous output. Ejection cycles can be internally timed, triggered manually, or synchronized to external events.

This flexible system allows the use of iontophoretic pump modules, pneumatic pump modules, or a combination of both. By interchanging the IP-2 Iontophoresis Pump Module with a PPM-2 pneumatic pressure pump, the overall system capability can be expanded for simultaneous pressure and iontophoretic injection of drugs from a multibarrel pipette.

The Neuro Phore BH-2 System was developed under the guidance of active researchers with extensive experience in iontophoresis techniques. These researchers needed a system to provide precise stimulation and quantitative control for ejection of drugs in their pharmacological studies of drug evoked responses such as neurosynaptic ischarges, contraction, and changes in chemical concentration. What emerged was a reliable, accurate, easy to use, Neuro Phore BH-2 system that is capable of accommodating high impedance multi-barreled micro-electrode pipettes.

Features

• Successfully utilized in key laboratories around the world for over 20 years, with many journal articles

published as a result

• Modular design; buy what you need now and add additional modules later as your protocol evolves

• Accommodates 7 barrel micropipettes, supports the most complex and demanding injection and recording protocols

• Extremely low noise, ±105 volts compliance, allows rapid iontophoretic injection with even the smallest micropipette tips

• Automatic current neutralization for minimal electrical artifacts

• Digitally controlled eject and pause timing utilizes easy to read and set digital panel switches on each iontophoretic or pressure module/channel

• Unbalance and out of compliance indicators are a great aid in troubleshooting clogged pipettes and other problems

• External analog input control allows external programming of complex, or closed loop injection protocols

• Current and electrode resistance readout with large bright easy to read digital displays

System Configuration

The Neuro Phore BH-2 System is modular and is comprised  f the following components (all ordered separately):

• One BH-2 Mainframe Chassis, BS4 65-0600 that can accommodate 1 to 5 Iontophoretic Pump and/or Pressure Pump Modules; Mainframe Chassis can be rack mounted or set on table

• One BM-2 Control and Balance Module, BS4 65-0602

• IP-2 Iontophoretic Pump Modules, BS4 65-0603 and/or

• PPM-2 Pressure Pump Modules, BS4 65-0604

• One low noise MS-2 Power Supply, BS4 65-0601

• Blank Panel DP-1 Dummy Module, BS4 65-0605 used to maintain timing if less than 5 Pump Modules are installed