FITC标记的兔抗甲状腺球蛋白
产品名称： FITC标记的兔抗甲状腺球蛋白
英文名称： Anti-TG/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
上海沪震实业有限公司
- 联系人 : 鲍丽雯
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Rabbit Anti-TG/FITC Conjugated antibody
| FITC标记的兔抗甲状腺球蛋白 |
| 英文名称 | Anti-TG/FITC |
| 中文名称 | FITC标记的兔抗甲状腺球蛋白 |
| 别 名 | Thyroglobulin; AITD 3; AITD3; hTG; TDH3; Tg; Tgn; THYG_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Cat, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 660kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | Thyroglobulin protein |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients. Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Thyroid gland specific. Post-translational modifications: Sulfated tyrosines are desulfated during iodination. DISEASE: Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Similarity: Belongs to the type-B carboxylesterase/lipase family. Contains 11 thyroglobulin type-1 domains. Database links: Entrez Gene: 7038 Human Entrez Gene: 21819 Mouse Entrez Gene: 24826 Rat Omim: 188450 Human SwissProt: P01266 Human SwissProt: O08710 Mouse SwissProt: P06882 Rat Unigene: 654591 Human Unigene: 441333 Mouse Unigene: 10429 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
甲状腺球蛋白是碘化甲状腺甲状腺素（T4）和三碘甲状腺原氨酸（T3）的糖蛋白前体。甲状腺球蛋白是从甲状腺获得的，具有球蛋白的一般性质。人甲状腺球蛋白（HTG）是在甲状腺滤泡细胞中发现的一种高分子量糖蛋白（605 kDa）。它在甲状腺、T4和T3的摄取、掺入和调节生物合成中起着中心作用。甲状腺疾病在很大程度上是由于自身免疫起源，抗甲状腺球蛋白自身抗体是第一个被发现的因素。在所有甲状腺自身免疫性疾病（Hashimoto甲状腺炎，Graves病）中发现抗HTG，在Hashimoto甲状腺炎中观察到最高水平。抗-HTG也是甲状腺癌的特征，其测定可用于癌症患者的随访。