Anti-CD209 Polyclonal Antibody
产品名称: Anti-CD209 Polyclonal Antibody
英文名称: Anti-CD209 Polyclonal Antibody
产品编号: K002796P
产品价格: null
产品产地: 北京
品牌商标: Solarbio
更新时间: 2025-12-22T13:19:53
使用范围:
北京索莱宝科技有限公司
- 联系人 : 索莱宝-龚思雨
- 地址 : 北京市北京经济技术开发区环科中路16号26幢3层301
- 邮编 :
- 所在区域 : 北京
- 电话 : 181****6239 点击查看
- 传真 : 点击查看
- 邮箱 : 3193328036@qq.com
- 二维码 : 点击查看
Anti-CD209 Polyclonal Antibody
品牌:solarbio | 货号:K002796P
| 英文名称 | Anti-CD209 Polyclonal Antibody |
|---|---|
| 别名 | CDSIGN;CLEC4L;DC-SIGN;DC-SIGN1 |
| 应用 | WB |
| 稀释比例 | WB 1:200-500. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 46kDa |
| Gene ID | 30835 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CD209 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CD209 |
| Subcellular Locations | Cell membrane Secreted Single-pass type II membrane protein |
| Swiss Prot | Q9NNX6 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. |
