AKT 小鼠单克隆抗体(1H2)
产品名称： AKT 小鼠单克隆抗体(1H2)
英文名称： AKT Mouse monoclonal antibody (1H2)
产品编号： LPA24478
产品价格： null
产品产地： 中国
品牌商标： Ablepscience
更新时间： null
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- 所在区域 : 湖北
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产品索引
产品数据
货号 LPA24478 文献 详细请查看官网 产品名称 AKT mouse Monoclonal Antibody(1H2) 中文名称 AKT 小鼠单克隆抗体(1H2) 规格 100ug 适应种属 Human 纯化方法 The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. UniProt ID 浓度 1mg/ml 宿主 Mouse 克隆性 Monoclonal 亚型 免疫原 Synthetic Peptide of AKT at AA range of 400-480 分子量 验证应用 WB,IHC-p 验证应用 Liquid 建议稀释比例 WB 1:1000-2000, IHC 1:100-200 存储条件 -20°C/1 year 偶联物 Unconjugated 储存溶液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. 运输条件 所有可选规格：常温运输或根据产品储存温度要求用蓝冰运输。 注意事项 该产品仅供科研使用
背景介绍
AKT serine/threonine kinase 1(AKT1) Homo sapiens The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]