分子量：Calculated MW: 13kDa/18kDa/20kDa/22kDa/26kDa/29kDa
Observed MW: 30kDa

细胞定位：Endoplasmic reticulum membrane, Multi-pass membrane protein

稀释方法：WB 1:500 - 1:2000

总结：This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene.