Anti-FAS(C-term) Monoclonal Antibody

品牌：Solarbio | 货号：K000037M

商品货号：	商品品牌：	规格	基本售价：	选择规格
K000037M-50ul	Solarbio	50ul	960.00元
K000037M-100ul	Solarbio	100ul	1600.00元

英文名称	Mouse FAS(C-term) Monoclonal Antibody
应用2	WB
克隆类型2	Monoclonal Antibody
别名	FAS(C-term)
应用	WB
稀释比例	WB1:1000
交叉反应	Human
蛋白分子量	45kDa
Gene ID	355
保存	Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 54% Glycerol.
纯化方法	Affinity purification
亚型	IgG1
免疫原	Purified recombinant human FAS (C-terminus) protein fragments expressed in E.coli.
性状	Lyophilized or Liquid
Swiss Prot	P25445
克隆号	4C3-G7-B7-H5
克隆类型	Monoclonal Antibody
来源	Mouse
背景资料	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.