FITC标记的促代谢型谷氨酸受体2+4抗体
产品名称： FITC标记的促代谢型谷氨酸受体2+4抗体
英文名称： Anti-GRM2+GRM4/FITC
产品编号： HZ-2139R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-GRM2+GRM4/FITC Conjugated antibody
FITC标记的促代谢型谷氨酸受体2+4抗体
| 英文名称 | Anti-GRM2+GRM4/FITC |
| 中文名称 | FITC标记的促代谢型谷氨酸受体2+4抗体 |
| 别 名 | Metabotropic Glutamate Receptor 2+4; GRM2+GRM4; GRM2 + GRM4; GRM2/GRM4; GPRC1B; GPRC1D; GRM2; GRM4; Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 4; mGluR2; mGluR4; GRM2_HUMAN; GRM4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 102kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GRM2+GRM4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Function: Receptor for glutamate. The activity of this receptor is mediated by a G protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Subcellular Location: Cell Membrane Database links: Entrez Gene: 2912 Human Entrez Gene: 2914 Human Entrez Gene: 24415 Rat Entrez Gene: 24417 Rat Omim: 604099 Human Omim: 604100 Human SwissProt: Q14416 Human SwissProt: Q14833 Human SwissProt: P31421 Rat SwissProt: P31423 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
谷氨酸是中枢神经系统中主要的兴奋性神经递质，同时激活离子型和代谢型谷氨酸受体。谷氨酸能神经传递涉及正常脑功能的大部分方面，在许多神经病理学条件下可能会受到干扰。代谢型谷氨酸受体是G蛋白偶联受体家族，根据序列同源性、推测的信号转导机制和药理特性，将其分为3组。I组包括GRM1和GRM5，这些受体已被证明激活磷脂酶C。II组包括GRM2和GRM3，而III组包括GRM4、GRM6、GRM7和GRM8。II和III受体与环AMP级联的抑制有关，但它们的激动剂选择性不同。