分子量：Calculated MW: 18kDa/42kDa
Observed MW: 38kDa

细胞定位：Endoplasmic reticulum membrane, Microsome membrane, Multi-pass membrane protein

稀释方法：WB 1:500 - 1:2000
IHC 1:50 - 1:200

总结：This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups. Mutations in this gene have been associated with leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia.