RASGRF1 (phospho S929) Peptide
产品名称： RASGRF1 (phospho S929) Peptide
英文名称： RASGRF1 (phospho S929) Peptide
产品编号： P1629
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of RASGRF1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S929 of human RASGRF1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells.
Iguchi T, Miyakawa Y, Saito K, Nakabayashi C, Nakanishi M, Saya H, Ikeda Y, Kizaki M.Int J Oncol. 2007 Aug;31(2):285-91.
- 2.
- Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1.
Holmes R, Chang Y, Soloway PD.Mol Cell Biol. 2006 Dec;26(24):9564-70. Epub 2006 Oct 9.
- Entrez GeneID:
- 5923
- Protein Accession#:
- NP_002882;Q13972
- Gene Name:
- RASGRF1
- Gene Alias:
- CDC25,CDC25L,GNRP,GRF1,GRF55,H-GRF55,PP13187
- Gene Description:
- Ras protein-specific guanine nucleotide-releasing factor 1
- Omim ID:
- 606600
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
- Other Designations:
- Ras-specific guanine nucleotide-releasing factor, CDC25 homolog,Ras-specific nucleotide exchange factor CDC25,guanine nucleotide exchange factor,guanine nucleotide-releasing factor, 55 kD
- Gene Pathway
- Related Disease