FITC标记的膜蛋白CLDND1抗体
产品名称： FITC标记的膜蛋白CLDND1抗体
英文名称： Anti-CLDND1/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CLDND1/FITC Conjugated antibody
FITC标记的膜蛋白CLDND1抗体
| 英文名称 | Anti-CLDND1/FITC |
| 中文名称 | FITC标记的膜蛋白CLDND1抗体 |
| 别 名 | C3orf4; Chromosome 3 open reading frame 4; Claudin domain containing 1; Claudin domain containing 1 protein; Membrane protein GENX3745; CLDN1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞粘附分子 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CLDND1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CLDND1 is a 253 amino acid multi-pass membrane protein that is expressed at high levels in adult brain and at lower levels in adult heart. Existing as two alternatively spliced isoforms, CLDND1 is encoded by a gene that maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. Subcellular Location: Membrane; Multi pass membrane protein. Tissue Specificity: Widely distributed in the adult CNS with highest expression in the corpus callosum, caudate nucleus, cerebral cortex, medulla, putamen, spinal cord, substantia nigra and subthalamic nucleus. Weak expression was detected in the adult heart. Similarity: Belongs to the PMP-22/EMP/MP20 family. Database links: UniProtKB/Swiss-Prot: Q9NY35.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CLDND1是大脑中高水平表达的253氨基酸多通道膜蛋白，在心脏中表达水平较低。CLDDN1存在于两个交替剪接的异构体中，其编码的基因映射到人类3号染色体，该基因包含1100个以上的基因，包括趋化因子受体（CKR）基因簇和多种人类癌症相关基因位点。3号染色体上的关键肿瘤抑制基因包括编码凋亡调节剂RASSF1、细胞迁移调节因子Hyal1和血管生成抑制因子SeMA3B。MARFAN综合征、卟啉症、Von Hippel Lindau综合征、成骨不全和玛丽牙症是少数。F与3号染色体相关的多种遗传疾病。