ADD1 polyclonal antibody
产品名称： ADD1 polyclonal antibody
英文名称： ADD1 polyclonal antibody
产品编号： PAB18058
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ADD1.
- Immunogen:
- A synthetic peptide corresponding to human ADD1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to ADD1.
- Form:
- Liquid
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunohistochemistry (1:50~1:100)
Immunofluorescence (1:500~1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c.
Kim KH, Song MJ, Yoo EJ, Choe SS, Park SD, Kim JB.J Biol Chem. 2004 Dec 10;279(50):51999-2006. Epub 2004 Oct 4.
- 2.
- Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2.
Tabor DE, Kim JB, Spiegelman BM, Edwards PA.J Biol Chem. 1999 Jul 16;274(29):20603-10.
- 3.
- ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose.
Foretz M, Pacot C, Dugail I, Lemarchand P, Guichard C, Le Liepvre X, Berthelier-Lubrano C, Spiegelman B, Kim JB, Ferre P, Foufelle F.Mol Cell Biol. 1999 May;19(5):3760-8.
- 4.
- ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand.
Kim JB, Wright HM, Wright M, Spiegelman BM.Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4333-7.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ADD1 polyclonal antibody (Cat # PAB18058).
Peptide "+" means "with peptide blocking".
- Entrez GeneID:
- 118
- Protein Accession#:
- P35611
- Gene Name:
- ADD1
- Gene Alias:
- ADDA,MGC3339,MGC44427
- Gene Description:
- adducin 1 (alpha)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq
- Other Designations:
- OTTHUMP00000151164,OTTHUMP00000151165,erythrocyte adducin alpha subunit
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- Albuminuria
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