Anti-SMC1A Polyclonal Antibody-抗体-抗体-生物在线
北京索莱宝科技有限公司--实验室产品
Anti-SMC1A Polyclonal Antibody

Anti-SMC1A Polyclonal Antibody

商家询价

产品名称: Anti-SMC1A Polyclonal Antibody

英文名称: CDLS2;DXS423E;SB1.8;SMC1;SMC1L1;SMC1alpha;SMCB

产品编号: K004935P

产品价格: null

产品产地: 北京

品牌商标: Solarbio

更新时间: null

使用范围: WB

北京索莱宝科技有限公司--实验室产品
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Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.