EGFR (phospho Y998) polyclonal antibody
产品名称: EGFR (phospho Y998) polyclonal antibody
英文名称: EGFR (phospho Y998) polyclonal antibody
产品编号: PAB0457
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of EGFR.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y998 of human EGFR.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- A basic peptide within the juxtamembrane region is required for EGF receptor dimerization.
Aifa S, Aydin J, Nordvall G, Lundstrom I, Svensson SP, Hermanson O.Exp Cell Res. 2005 Jan 1;302(1):108-14.
- 2.
- EGF signalling amplification induced by dynamic clustering of EGFR.
Ichinose J, Murata M, Yanagida T, Sako Y.Biochem Biophys Res Commun. 2004 Nov 19;324(3):1143-9.
- 3.
- Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor.
Adams TE, McKern NM, Ward CW.Growth Factors. 2004 Jun;22(2):89-95.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis using EGFR (pY998) polyclonal antibody (Cat # PAB0457) to detect EGFR in A413 cell lysate, H1299 cell lysate and H1299 cell treated with EGF 10 ng/ml for 10 min. Loading 50 ug total protein each well, and EGFR (pY998) polyclonal antibody were diluted 1:1000. GAPDH were used as loading control.
- Entrez GeneID:
- 1956
- Protein Accession#:
- NP_005219;P00533
- Gene Name:
- EGFR
- Gene Alias:
- ERBB,ERBB1,HER1,PIG61,mENA
- Gene Description:
- epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq
- Other Designations:
- avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,cell growth inhibiting protein 40,cell proliferation-inducing protein 61,epidermal growth factor receptor
- Interactome
- Gene Pathway
- Adherens junction
- Bladder cancer
- Calcium signaling pathway
- Colorectal cancer
- Cytokine-cytokine receptor interaction
- Dorso-ventral axis formation
- Endocytosis
- Endometrial cancer
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Focal adhesion
- Gap junction
- Glioma
- GnRH signaling pathway
- MAPK signaling pathway
- Melanoma
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Regulation of actin cytoskeleton
- Related Disease
- Adenocarcinoma
- Adenocarcinoma, Bronchiolo-Alveolar
- Adenocarcinoma, Mucinous
- Adenocarcinoma, Papillary
- Anus Neoplasms
- Asthma
- Asthma
- Astrocytoma
- Atherosclerosis
- Barrett Esophagus
- Bile Duct Neoplasms
- Biliary Tract Neoplasms
- Bipolar Disorder
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Bronchial Hyperreactivity
- Carcinoma
- Carcinoma, Adenosquamous