产品概述：Purified recombinant protein of Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), Met1-Tyr50-GGGGS-Gly600-Ile700, with N-terminal His tag, expressed in E.coli, 50ug

蛋白长度：A DNA sequence encoding the region (Met1-Tyr50-GGGGS-Gly600-Ile700) of ABCB1

表达系统：E. coli

种属：Human

标签类型：N-His

分子量：17.6 kDa

通用名：ABCB1

总结：The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]

形式：Liquid

浓度：>50 ug/mL as determined by microplate BCA method

纯度：>80% as determined by SDS-PAGE and Coomassie blue staining

储存溶液：50mM Tris, pH8.0, 8M Urea

别名：ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1