分子量：Calculated MW: 43kDa/47kDa/71kDa
Observed MW: 64kDa

细胞定位：Secreted, extracellular space

稀释方法：WB 1:500 - 1:2000
IHC 1:50 - 1:200

总结：This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.