FITC标记的KDELR2蛋白抗体
产品名称： FITC标记的KDELR2蛋白抗体
英文名称： Anti-KDELR2/FITC
产品编号： HZ-16941R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-KDELR2/FITC Conjugated antibody
FITC标记的KDELR2蛋白抗体
| 英文名称 | Anti-KDELR2/FITC |
| 中文名称 | FITC标记的KDELR2蛋白抗体 |
| 别 名 | Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 2; ELP 1; ELP-1; ELP1; ER lumen protein retaining receptor 2; ERD 2 like protein; ERD2 like protein 1; ERD2-like protein 1; ERD2.2; ERD22_HUMAN; FLJ45532; KDEL (Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2; KDELR 2; kdelr2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 跨膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KDELR2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Function: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L. Subcellular Location: Endoplasmic reticulum membrane. Similarity: Belongs to the ERD2 family. Database links: Entrez Gene: 11014 Human Entrez Gene: 66913 Mouse Entrez Gene: 304290 Rat Omim: 609024 Human SwissProt: P33947 Human SwissProt: Q9CQM2 Mouse SwissProt: Q5U305 Rat Unigene: 654552 Human Unigene: 705873 Human Unigene: 181880 Mouse Unigene: 4066 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
在酵母和动物细胞中，通过持续从顺式高尔基体或前高尔基体室中取出可溶性蛋白质，在内质网(ER)的腔中保持可溶性蛋白质。这些蛋白质的分类依赖于C端四肽信号，通常是动物细胞中的lys-asp-glu-leu(KDEL)和酿酒酵母中的his-asp-glu-leu(HDEL)。该过程由识别并结合四肽的蛋白质的受体介导，并将其返回给ER。在酵母中，由单个基因Erd2编码的分拣受体是七跨膜蛋白。与酵母不同，已经描述了构成KDEL受体基因家族的Erd2基因的几个人类同源物。KDELR2是第二个被鉴定的家族成员，它编码一个与KDELR1基因产物83%相同的蛋白。选择性剪接导致多个转录变体编码不同的亚型。[ RefSeq，JUL 2008 ]