FITC标记的磷酸化α晶状体球蛋白B/αB-crystallin抗体
产品名称： FITC标记的磷酸化α晶状体球蛋白B/αB-crystallin抗体
英文名称： Anti-phospho-alpha B Crystallin (Ser45)/FITC
产品编号： HZ-12970R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-phospho-alpha B Crystallin (Ser45)/FITC Conjugated antibody
FITC标记的磷酸化α晶状体球蛋白B/αB-crystallin抗体
| 英文名称 | Anti-phospho-alpha B Crystallin (Ser45)/FITC |
| 中文名称 | FITC标记的磷酸化α晶状体球蛋白B/αB-crystallin抗体 |
| 别 名 | alpha B Crystallin (phospho S45); alpha B Crystallin (phospho Ser45); p-alpha B Crystallin (S45); p-alpha B Crystallin (Ser45); AACRYA; Alpha B crystallin; Alpha crystallin B chain; Alpha crystallin B chain; Alpha(B) crystallin; Alpha(B)-crystallin; Alpha-crystallin B chain; CRYA2; CRYAB; CRYAB_HUMAN; Crystallin alpha B; Crystallin alpha polypeptide 2; CTPP 2; CTPP2; Heat shock 20 kD like protein; Heat shock protein beta 5; Heat shock protein beta-5; HSPB5; NY REN 27 antigen; Renal carcinoma antigen NY REN 27; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser45 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008]. Function: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Subunit: Heteropolymer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Interacts with HSPBAP1 and TTN/titin. Subcellular Location: Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Tissue Specificity: Lens as well as other tissues. DISEASE: Defects in CRYAB are the cause of myopathy myofibrillar type 2 (MFM2) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients. [DISEASE] Defects in CRYAB are the cause of cataract posterior polar type 2 (CTPP2) [MIM:613763]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity. [DISEASE] Defects in CRYAB are the cause of myopathy myofibrillar fatal infantile hypertonic alpha-B crystallin-related (MFMFIH-CRYAB) [MIM:613869]. MFMFIH-CRYAB is a muscular dystrophy with onset in the first weeks of life after a normal neonatal period. Affected infants show rapidly progressive muscular rigidity of the trunk and limbs associated with increasing respiratory difficulty resulting in death before age 3 years. Similarity: Belongs to the small heat shock protein (HSP20) family. Database links: Entrez Gene: 1410 Human Entrez Gene: 12955 Mouse Entrez Gene: 25420 Rat Omim: 123590 Human SwissProt: P02511 Human SwissProt: P23927 Mouse SwissProt: P23928 Rat Unigene: 53454 Human Unigene: 178 Mouse Unigene: 98208 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
晶状体被分为两类：类群特异的或酶的，普遍存在的。后者是脊椎动物眼晶状体的主要蛋白质，维持晶状体的透明度和折射率。由于晶状体中心纤维细胞在发育过程中失去细胞核，这些晶体被制成，并在整个生命中保留下来，使它们成为极其稳定的蛋白质。哺乳动物晶状体结晶分为α、β和伽马家族，β和伽马晶体也被认为是超家族。α和β族进一步分为酸性基团和碱性基团。晶体蛋白中存在七个蛋白区：四个同源基序，一个连接肽，和N-末端和C-末端延伸。α-晶状体蛋白由两个基因产物组成：α-A和α-B，分别为酸性和碱性。α晶体可由热休克诱导，并且是小热休克蛋白（sHSP，也称为HSP20）家族的成员。它们作为分子伴侣起作用，虽然它们不使蛋白质复性并以真正的伴侣的方式释放蛋白质；相反，它们以大的可溶性聚集体保持蛋白质。翻译后修饰降低了伴侣伴侣的能力。这些非均相聚集体由30-40个亚基组成，α-A和α-B亚基的比例分别为3:1。α晶状体蛋白的两个附加功能是自身激酶活性和参与细胞内结构。α-A和α-B基因产物表达不同，α-A优先限于晶状体，α-B在许多组织和器官中广泛表达。α-B晶体蛋白的高表达出现在许多神经疾病中；错义突变在结蛋白相关肌病家族中共同聚集。[ RefSeq，JUL 2008 ]提供。