FITC标记的信号调节蛋白β2/SIRP-β2抗体
产品名称： FITC标记的信号调节蛋白β2/SIRP-β2抗体
英文名称： Anti-SIRPB2/FITC
产品编号： HZ-17499R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SIRPB2/FITC Conjugated antibody
FITC标记的信号调节蛋白β2/SIRP-β2抗体
| 英文名称 | Anti-SIRPB2/FITC |
| 中文名称 | FITC标记的信号调节蛋白β2/SIRP-β2抗体 |
| 别 名 | BIG 3; dJ776F14.2; Protein tyrosine phosphatase non-receptor type substrate 1-like 3; Protein tyrosine phosphatase non-receptor type substrate protein; PTPNS1L3; RP4-776F14.1; Signal-regulatory protein beta-2; SIRB2_HUMAN; SIRP-beta-2; SIRPB2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SIRPB2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: SIRPs are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domain-containing protein-tyrosine phosphatase SHP-2 in response to insulin. The SIRP family negatively regulates the PI 3-kinase pathway, which may diminish EGFR-mediated motility and survival phenotypes that contribute to transformation of certain cell types. SIRP-alpha 1 is a transmembrane protein which acts as a substrate for activated receptor tyrosine kinases and, in its tyrosine phosphorylated form, binds to SH-PTP2 through SH2 interactions and acts as an SH-PTP2 substrate. SIRP-alpha 1 has been shown to have negative regulatory effects on cellular responses induced by growth factors, oncogenes and Insulin. SIRP-beta 1 shares extensive sequence homology with SIRP-alpha 1 in its extracellular portion but lacks the cytoplasmic portion. SIRP-beta 2 is a 342 amino acid multi-pass membrane protein that contains two Ig-like V-type (immunoglobulin-like) domains and exists as multiple alternatively spliced isoforms. Subcellular Location: Membrane. Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains. Database links: Entrez Gene: 284759 Human SwissProt: Q5JXA9 Human Unigene: 721685 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SIRP是一种跨膜糖蛋白家族，它们通过与Src同源性2结构域相关的蛋白酪氨酸磷酸酶SpP-2与胰岛素反应而鉴定。SIRP家族负调控PI 3-激酶途径，这可能减少EGFR介导的运动和存活表型，有助于某些细胞类型的转化。SIRP-α1是一种跨膜蛋白，其作为活化受体酪氨酸激酶的底物，并以其酪氨酸磷酸化的形式，通过SH2相互作用与SH-PTP2结合，并作为SH-PTP2底物。SIRP-α1对生长因子、癌基因和胰岛素诱导的细胞应答具有负调节作用。SIRPβ1在其胞外部分与SIRPα1具有广泛的序列同源性，但缺少细胞质部分。SIRP-β2是一种342个氨基酸的多程膜蛋白，含有两个Ig样V型（免疫球蛋白样）结构域，以多种选择性剪接异构体存在。