GCKR (N-term) Peptide
产品名称： GCKR (N-term) Peptide
英文名称： GCKR (N-term) Peptide
产品编号： P3167
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of GCKR.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human GCKR.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians.
Veiga-da-Cunha M, Delplanque J, Gillain A, Bonthron DT, Boutin P, Van Schaftingen E, Froguel P.Diabetologia. 2003 May;46(5):704-11. Epub 2003 May 9.
- 2.
- Organization of the human glucokinase regulator gene GCKR.
Hayward BE, Dunlop N, Intody S, Leek JP, Markham AF, Warner JP, Bonthron DT.Genomics. 1998 Apr 1;49(1):137-42.
- 3.
- Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23.
Hayward BE, Fantes JA, Warner JP, Intody S, Leek JP, Markham AF, Bonthron DT.Mamm Genome. 1996 Jun;7(6):454-8.
- Applications
- Western Blot (Cell lysate)
- The GCKR polyclonal antibody (Cat # PAB4013) is used in Western blot to detect GCKR in A-375 cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with GCKR polyclonal antibody (Cat # PAB4013) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 2646
- Protein Accession#:
- Q14397
- Gene Name:
- GCKR
- Gene Alias:
- GKRP
- Gene Description:
- glucokinase (hexokinase 4) regulator
- Omim ID:
- 600842
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq
- Other Designations:
- glucokinase (hexokinase 4) regulatory protein,glucokinase regulator,glucokinase regulatory protein,hexokinase 4
- Related Disease
- Albuminuria
- Alzheimer Disease
- Atherosclerosis
- Birth Weight
- Brain Ischemia
- Cardiovascular Diseases
- Colitis, Ulcerative
- Coronary Artery Disease
- Crohn Disease
- Crohn's disease
- Dementia
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Dyslipidemias
- Edema
- Genetic Predisposition to Disease
- Glucose Intolerance
- Gout
- HIV Infections