分子量：Calculated MW: 20kDa/35kDa/39kDa/41kDa
Observed MW: 50kDa

细胞定位：Nucleus matrix

稀释方法：WB 1:500 - 1:2000
IF 1:50 - 1:200

总结：Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.