DIABLO polyclonal antibody
产品名称： DIABLO polyclonal antibody
英文名称： DIABLO polyclonal antibody
产品编号： PAB13089
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of DIABLO.
- Immunogen:
- A synthetic peptide corresponding to amino acids 225-239 of human DIABLO.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- human heart tissue lysate can be used as positive control and a 25 KDa band can be detected.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z, Alnemri ES.J Biol Chem. 2000 Nov 17;275(46):36152-7.
- 2.
- Structural and biochemical basis of apoptotic activation by Smac/DIABLO.
Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y.Nature. 2000 Aug 24;406(6798):855-62.
- 3.
- Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
Du C, Fang M, Li Y, Li L, Wang X.Cell. 2000 Jul 7;102(1):33-42.
- Entrez GeneID:
- 56616
- Protein Accession#:
- AAF87716
- Gene Name:
- DIABLO
- Gene Alias:
- DIABLO-S,FLJ10537,FLJ25049,SMAC,SMAC3
- Gene Description:
- diablo homolog (Drosophila)
- Omim ID:
- 605219
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. [provided by RefSeq
- Other Designations:
- 0610041G12Rik,diablo,direct IAP-binding protein with low pI,mitochondrial Smac protein,second mitochondria-derived activator of caspase
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