FITC标记的程序性死亡1抗体
产品名称： FITC标记的程序性死亡1抗体
英文名称： Anti-PD-1/FITC
产品编号： HZ-1867R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-PD-1/FITC Conjugated antibody
FITC标记的程序性死亡1抗体
| 英文名称 | Anti-PD-1/FITC |
| 中文名称 | FITC标记的程序性死亡1抗体 |
| 别 名 | CD279; CD279 antigen; hPD 1; hPD l; hPD-1; hSLE1; PD 1; PD1; PDCD 1; PDCD1; PDCD1_HUMAN; Programmed cell death 1; Programmed cell death protein 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Rabbit, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PD-1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. CD279 is an immunoglobulin superfamily member, also known as Programmed Cell Death 1. Programmed Cell Death 1 is expressed on a subset of CD4-CD8 thymocytes, and on activated T and B cells. Programmed Cell Death 1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The Programmed Cell Death 1 ligands, PDL1 (also known as B7H1) and PDL2 (B7DC), are members of the B7 immunoglobulin superfamily. Function: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. Subunit: Monomer. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Ta,Ba,Ma,Thy DISEASE: Systemic lupus erythematosus 2 (SLEB2) [MIM:605218]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:12402038}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 5133 Human Entrez Gene: 18566 Mouse Entrez Gene: 301626 Rat Omim: 600244 Human SwissProt: Q15116 Human SwissProt: Q02242 Mouse Unigene: 158297 Human Unigene: 5024 Mouse Unigene: 105023 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 配体为B7H1/PDL1(CD274)和B7DC/PDL2，抑制活化T细胞的增殖和细胞因子的产生，抑制B细胞功能，参与免疫耐受 |
该基因编码免疫球蛋白超家族的细胞表面膜蛋白。这种蛋白在PR-B细胞中表达，并被认为在其分化中起作用。在小鼠中，当注射抗CD3抗体和大量胸腺细胞发生凋亡时，在胸腺中诱导该基因的表达。该基因在BALB/c背景下缺失的小鼠发展为扩张型心肌病并死于充血性心力衰竭。这些研究表明，该基因产物在T细胞功能中也很重要，有助于自身免疫性疾病的预防。
CD27 9是一种免疫球蛋白超家族成员，又称程序性细胞死亡1。程序性细胞死亡1在CD4-CD8胸腺细胞和活化的T细胞和B细胞上表达。程序性细胞死亡1被认为参与淋巴细胞克隆选择和外周耐受。程序化的细胞死亡1配体，PDL1（也称为B7H1）和PDL2（B7DC），是B7免疫球蛋白超家族的成员。