FITC标记的FBXW10蛋白抗体
产品名称： FITC标记的FBXW10蛋白抗体
英文名称： Anti-FBXW10/FITC
产品编号： HZ-16054R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FBXW10/FITC Conjugated antibody
FITC标记的FBXW10蛋白抗体
| 英文名称 | Anti-FBXW10/FITC |
| 中文名称 | FITC标记的FBXW10蛋白抗体 |
| 别 名 | F-box and WD-40 domain-containing protein 10; F-box/WD repeat-containing protein 10; FBW10_HUMAN; FBXW10; Ubiquitin ligase-specificity factor. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 120kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FBXW10 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes, including the cell cycle, immune responses, signaling cascades and developmental events, through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for proteasomal degradation. FBXW10 (F-box and WD repeat domain containing 10), also known as protein Ubiquitin ligase-specificity factor, is a 1,052 amino acid protein that contains one F-box domain and seven WD repeats. Existing as four alternatively spliced isoforms, FBXW10 induces degradation of CBX5 and CBX1. Function: Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. Similarity: Contains 1 F-box domain. Contains 7 WD repeats. Database links: Entrez Gene: 10517 Human Omim: 611679 Human SwissProt: Q5XX13 Human Unigene: 592128 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
F-box蛋白是SCF(Skp1-CUL-1-F-box蛋白)型E3泛素连接酶复合物的关键成分，参与底物识别和泛素化募集。它们属于一个较大的蛋白家族，通过靶向诸如细胞周期素、细胞周期素依赖性激酶抑制剂等蛋白质，参与调节各种细胞过程，包括细胞周期、免疫应答、信号级联和发育事件。S，ⅠB -β-和β-连环蛋白，用于蛋白酶体降解。FBXW10(F-box和WD重复结构域含10)，又称泛素连接酶特异性因子，是一种1052个氨基酸的蛋白质，含有一个F-box结构域和7个WD重复序列。作为四替代SPLI存在