NUP98 monoclonal antibody, clone 2H10
产品名称： NUP98 monoclonal antibody, clone 2H10
英文名称： NUP98 monoclonal antibody, clone 2H10
产品编号： MAB6758
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rat monoclonal antibody raised against partial recombinant NUP98.
- Immunogen:
- Recombinant GST fusion protein corresponding to amino acids 1-466 of human NUP98.
- Host:
- Rat
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Isotype:
- IgG2c, kappa
- Storage Buffer:
- In PBS (50% glycerol, azide free)
- Storage Instruction:
- Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- NUP98 dysregulation in myeloid leukemogenesis.
Moore MA, Chung KY, Plasilova M, Schuringa JJ, Shieh JH, Zhou P, Morrone G.Ann N Y Acad Sci. 2007 Jun;1106:114-42. Epub 2007 Apr 18.
- 2.
- Specific monoclonal antibody against the nuclear pore complex protein, nup98.
Fukuhara T, Ozaki T, Shikata K, Katahira J, Yoneda Y, Ogino K, Tachibana T.Hybridoma (Larchmt). 2005 Oct;24(5):244-7.
- 3.
- Nup98 is a mobile nucleoporin with transcription-dependent dynamics.
Griffis ER, Altan N, Lippincott-Schwartz J, Powers MA.Mol Biol Cell. 2002 Apr;13(4):1282-97.
- Applications
- Western Blot (Cell lysate)
- Detection of NUP98 protein with NUP98 monoclonal antibody, clone 2H10 (Cat # MAB6758). Sample is HeLa nuclear membrane fraction. The IgG solution was 2,000-fold diluted before use.
- Entrez GeneID:
- 4928
- Gene Name:
- NUP98
- Gene Alias:
- ADIR2,NUP196,NUP96
- Gene Description:
- nucleoporin 98kDa
- Omim ID:
- 601021
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
- Other Designations:
- GLFG-repeat containing nucleoporin,Nup98-Nup96,OTTHUMP00000013819,OTTHUMP00000013967,nucleoporin 98kD
- Related Disease