FITC标记的钾通道相互作用蛋白2抗体
产品名称： FITC标记的钾通道相互作用蛋白2抗体
英文名称： Anti-KChIP2/FITC
产品编号： HZ-9441R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-KChIP2/FITC Conjugated antibody
FITC标记的钾通道相互作用蛋白2抗体
| 产品编号 | bs-9441R-FITC |
| 英文名称 | Anti-KChIP2/FITC |
| 中文名称 | FITC标记的钾通道相互作用蛋白2抗体 |
| 别 名 | KCNIP-2; A type potassium channel modulatory protein 2; A-type potassium channel modulatory protein 2; Cardiac voltage gated potassium channel modulatory subunit; Cardiac voltage-gated potassium channel modulatory subunit; DKFZp566L1246; KChIP 2; KChIP2; KCIP2_HUMAN; KCNIP 2; Kcnip2; Kv channel interacting protein 2; Kv channel-interacting protein 2; MGC17241; Potassium channel interacting protein 2; Potassium channel-interacting protein 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 神经生物学 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KChIP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The downstream regulatory element, DRE, acts as a location-dependent gene silencer. DREAM (for DRE-antagonist modulator) is a Ca2+-regulated transcriptional repressor that specifically binds to the DRE. DREAM regulates transcription of prodynorphin and c-Fos genes and shows 99% nucleotide homology to the Kv channel-interacting proteins (KChIPs). KChIP family members include KChIP1, which is expressed in brain, KChIP2, which is expressed in heart, brain, and lung, KChIP3 (also designated calsenilin), which is expressed in brain and testis and KChIP4. Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface (By similarity). Subunit: Component of heteromultimeric potassium channels. The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with KCND2. Isoform 1 and isoform 3 interact with KCND3 isoform 1. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. At least isoform 2 and isoform 3 can self-associate to form homodimers and homotetramers. Isoform 3 interacts with KCNIP1 in a calcium-dependent manner. Subcellular Location: Cell membrane. Tissue Specificity: Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart. Post-translational modifications: Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity). Similarity: Belongs to the recoverin family. Contains 4 EF-hand domains. Database links: Entrez Gene: 30819 Human Entrez Gene: 80906 Mouse Entrez Gene: 56817 Rat Entrez Gene: 619380 Rat Omim: 604661 Human SwissProt: Q9NS61 Human SwissProt: Q9JJ69 Mouse SwissProt: Q9JM59 Rat Unigene: 97044 Human Unigene: 213204 Mouse Unigene: 98384 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
下游调控元件DRE作为位置依赖基因沉默子。DRE（DRE拮抗剂调节剂）是一种与DRE特异结合的Ca2+调控转录抑制子。梦调节前强啡肽和c-fos基因的转录，并与KV通道相互作用蛋白（k薯片）显示99%核苷酸同源性。KChIP家族成员包括KCHIP1，其在脑、脑和肺中表达，KCHIP2，KCHIP3（也指定钙素），其表达于脑和睾丸和KCHIP4。