分子量：Calculated MW: 106kDa
Observed MW: 110kDa

细胞定位：Nucleus

稀释方法：WB 1:500 - 1:2000

总结：The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.