FITC标记的钙结合蛋白39抗体
产品名称： FITC标记的钙结合蛋白39抗体
英文名称： Anti-CAB39/FITC
产品编号： HZ-3636R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CAB39/FITC Conjugated antibody
FITC标记的钙结合蛋白39抗体
| 英文名称 | Anti-CAB39/FITC |
| 中文名称 | FITC标记的钙结合蛋白39抗体 |
| 别 名 | CAB39; Calcium binding protein 39; CGI 66; CGI66; MO25 alpha; MO25; Mouse protein 25 alpha; Protein Mo25. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MO25 alpha/CAB39 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Mouse protein 25 alpha (MO25 alpha, CAB39) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). CAB39 binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms. Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Subcellular Location: Cytoplasm Similarity: Belongs to the Mo25 family. Database links: Entrez Gene: 51719 Human Entrez Gene: 12283 Mouse Entrez Gene: 301574 Rat Omim: 612174 Human SwissProt: Q9Y376 Human SwissProt: Q06138 Mouse Unigene: 603930 Human Unigene: 26135 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
小鼠蛋白25α（MO25α，CAB39）是40 kDa蛋白，与STE20相关适配器α（STARADα）伪激酶一起形成能够刺激LKB1肿瘤抑制蛋白激酶活性的调节复合物。后者在遗传性Putz JeHHER癌症综合征（PJS）中发生突变。CAB39直接在STARADαC末端与保守的Trp- Glu PHE序列结合，显著增强STRADα与LKB1的结合，并增加LKB1催化活性。骨骼肌收缩通过上游激酶（AMPKK）导致AMP活化蛋白激酶（AMPK）的磷酸化和活化。LKB1 STE相关适配器（STRAD）-小鼠蛋白25（MO25）复合物是骨骼肌中的主要AMPKK；然而，LKB1-STAD-MO25活性不是由肌肉收缩增加的。这种关系表明，在骨骼肌收缩过程中，LKB1-STRAD-MO25磷酸化AMPK可通过变构机制调节。