FITC标记的CD344抗体
产品名称： FITC标记的CD344抗体
英文名称： Anti-Frizzled 4/FITC
产品编号： HZ-13217R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Frizzled 4/FITC Conjugated antibody
FITC标记的CD344抗体
| 英文名称 | Anti-Frizzled 4/FITC |
| 中文名称 | FITC标记的CD344抗体 |
| 别 名 | CD 344; CD 344 antigen; CD344; CD344 antigen; EVR1; FEVR; Frizzled (Drosophila) homolog 4; Frizzled 4; Frizzled family receptor 4; Frizzled homolog 4 (Drosophila); Frizzled-4; Fz 4; Fz-4; Fz4; FZD4; FZD4_HUMAN; FZD4S; FzE4; GPCR; hFz4; MGC34390; WNT receptor frizzled 4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 发育生物学 信号转导 干细胞 转录调节因子 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Frizzled 4/CD344 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Frizzled-4 is a 537 amino acid protein encoded by the human gene FZD4. Frizzled-4 acts as a receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Frizzled-4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Frizzled-4 also plays a critical role in retinal angiogenesis. Frizzled-4 is virtually ubiquitously expressed with greatest amounts found in adult heart, skeletal muscle, ovary, and fetal kidney. Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Subunit: Interacts with MAGI3 and norrin (NDP). Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP) (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Tissue Specificity: Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver. Post-translational modifications: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. DISEASE: Defects in FZD4 are the cause of vitreoretinopathy exudative type 1 (EVR1) [MIM:133780]; also known as autosomal dominant familial exudative vitreoretinopathy (FEVR) or Criswick-Schepens syndrome. EVR1 is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease-related abnormality is an arc of avascular retina in the extreme temporal periphery. Similarity: Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain. Database links: Entrez Gene: 8322 Human Entrez Gene: 14366 Mouse Entrez Gene: 64558 Rat Omim: 604579 Human SwissProt: Q9ULV1 Human SwissProt: Q61088 Mouse SwissProt: Q9QZH0 Rat Unigene: 591968 Human Unigene: 86755 Mouse Unigene: 48736 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FruZel-4是由人类基因FZD4编码的537氨基酸蛋白。FRZZED-4作为Wnt蛋白的受体。大多数褶皱受体与β-连环素信号转导途径偶联，导致蛋白失调、GSK-3激酶抑制、β-连环素的核积累和Wnt靶基因的激活。对于某些家族成员已经发现了涉及PKC和钙通量的第二条信号通路，但是目前尚不清楚它是否代表一条不同的通路，或者它是否可以整合到正则通路中，因为PKC似乎是Wnt介导的GSK-3激酶失活所必需的。这两个途径似乎涉及与G蛋白的相互作用。Frizzled-4可能参与组织形态发生和/或分化组织中极性信息的转导和细胞间传递。FraseDel-4在视网膜血管生成中也起着关键作用。Frizzled-4在成人心脏、骨骼肌、卵巢和胎儿肾脏中几乎无处不在。