SIGLEC12 monoclonal antibody (M01), clone 1D1
产品名称： SIGLEC12 monoclonal antibody (M01), clone 1D1
英文名称： SIGLEC12 monoclonal antibody (M01), clone 1D1
产品编号： H00089858-M01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant SIGLEC12.
- Immunogen:
- SIGLEC12 (NP_443729.1, 503 a.a. ~ 595 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- RSCRKKSARPAVGVGDTGMEDANAVRGSASQGPLIESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQEAIGYEYSEINIPK
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.97 KDa) .
- MSDS:
Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of SIGLEC12 expression in transfected 293T cell line by SIGLEC12 monoclonal antibody (M01), clone 1D1.
Lane 1: SIGLEC12 transfected lysate (Predicted MW: 65 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged SIGLEC12 is 0.3 ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 89858
- GeneBank Accession#:
- NM_053003
- Protein Accession#:
- NP_443729.1
- Gene Name:
- SIGLEC12
- Gene Alias:
- FLJ38600,S2V,SIGLECL1,SLG,Siglec-12,Siglec-L1,Siglec-XII
- Gene Description:
- sialic acid binding Ig-like lectin 12
- Omim ID:
- 606094
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- SIGLEC-like 1,sialic acid binding immunoglobulin-like lectin-like protein 1
- Related Disease