DMAP1 (C-term) Peptide
产品名称： DMAP1 (C-term) Peptide
英文名称： DMAP1 (C-term) Peptide
产品编号： P1744
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of DMAP1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human DMAP1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.
Rountree MR, Bachman KE, Baylin SB.Nat Genet. 2000 Jul;25(3):269-77.
- Applications
- Western Blot (Cell lysate)
- The DMAP1 polyclonal antibody (Cat # PAB1977) is used in Western blot to detect DMAP1 in HL-60 cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with DMAP1 polyclonal antibody (Cat # PAB1977), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 55929
- Protein Accession#:
- NP_061973
- Gene Name:
- DMAP1
- Gene Alias:
- DKFZp686L09142,DNMAP1,DNMTAP1,EAF2,FLJ11543,KIAA1425,SWC4
- Gene Description:
- DNA methyltransferase 1 associated protein 1
- Omim ID:
- 605077
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
- Other Designations:
- DNMT1 associated protein 1,OTTHUMP00000008845,OTTHUMP00000008846,OTTHUMP00000008847